The sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE)has been widely used for protein separation because it is a simple and reliable method.With the recent introduction of micro-fabrication process into the micro-fluidic device field,successful separations of proteins using the micro-channel-based structure have been reported.However,the system often requires complicated fluorescence chemicals to identify proteins and a high operation electrical field.A new micro-channel device fabricated on a silicon wafer has been developed.The channel structure was with the silicon technology including the lithography process,thin film deposition,and etching.The device has been effective in separating proteins from a mixture.In principle,it can also be used to further separate other biomolecules such as DNA.
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