Encapsulation of ibuprofen in mesoporous silica: solid state NMR characterization

摘要

Mesoporous silica materials have been studied for the time-dependent delivery of bioactive agents. It has already been shown that ibuprofen molecules can be encapsulated with loading as high as 30 wt% in MCM-41 silica, functionalized or not by amtno groups. Interactions between the guest molecules and the host matrix have been investigated by ~H, ~(29)Si and ~(13)C solid state NMR spectroscopy. These experiments demonstrate an extremely high mobility of the ibuprofen molecules when the matrix is not functionalized, despite of the presence of a carboxylic function on the ibuprofen molecules. On the contrary, when the silica matrix is functionalized by amino groups, the ~(13)C NMR response shows a strong restriction in mobility suggesting the existence of interactions between the amino groups and the carboxylic groups.