Effects of protective clothing on the skin penetration of xenobiotics

摘要

Systemic absorption following dermal exposure to chemicals is potentially hazardous. The ability of several glove materials to reduce skin permeation of a variety of compounds (including agrochemical and cosmetic materials) has been determined using excised human skin in vitro. In addition to monitoring permeation through glove materials, skin and glove/skin combinations, the uptake of chemicals into glove materials was evaluated. The results demonstrated that realistic performance evaluation procedures for protective materials must take into account many factors. There are numerous questions to be considered other than straihtforward permeation of chemicals through glove materials and the availability of additional information pertaining to such actual and potential hazards would aid selection of appropriate materials and increase safety margins.