A study on glycemic control of critically ill patients with time-varying insulin sensitivity using nonlinear model predictive control

摘要

In critically ill patients with hyperglycemia, it has been recently shown that mortality and morbidity can be reduced by keeping glycemia within 80-110 mg/dL. However, it is not easy to regulate their blood glucose levels due to time variability of insulin sensitivity. In this study, we develop a nonlinear model predictive blood glucose control system using the Continuation Generalized Minimum RESidual (C/GMRES) method. Simulation results show that, in patients with time-varying insulin sensitivity, glycemia can be regulated within desirable levels during continuous parenteral glucose delivery.