A muscle relaxant control system under total intravenous anesthesia

摘要

Under general anesthesia during surgical operations, three elements of anesthesia, i.e. sedation, analgesia, and muscle relaxant of patients are needed to keep at the appropriate levels respectively. In this paper, control of muscle relaxant under total intravenous anesthesia, which all elements of anesthesia are maintained by intravenous anesthetic drugs, is studied, and a muscle relaxant control system using a state-predictive controller has been developed. Vecuronium is used as a muscle relaxant and twitch response is used as an available index of muscle relaxation. In order to cope with individual differences, our system has an on-line identification function. The performance of our system is evaluated by simulations.