THE ROLE ARACHIDONIC ACID METABOLITES IN THE RESPONSE OF GUINEA PIG LUNG AND DERMAL VASCULATURE TO EXTRACTS OF COTTON DUST

摘要

The ability of cotton dust extract (CDE) to release Inflammatory mediators have been considered to play a role in the development of byssinosis. In this study, an experimental model of guinea pig lung perfusion has been employed to examine the effect of previous exposure to CDE on the pulmonary perfusion pressure (PPP) and to study the release and pulmonary activity of arachidonic acid (AA) metabolites. In addition, the possibility of CDE acting as a sensitizing agent has been examined using a cutaneous reaction test.