(281f) Omics Analysis of Agrobacterium Sp. Uncovers Regulatory Factors for Polysaccharide Biosynthesis

摘要

Microbial polysaccharides are primary cellular components and integral to many cellular functions including cell adhesion, biofilm formation, pathogenesis, and protection from the environment. Despite their ubiquity and functional importance, the regulation of polysaccharide biosynthesis remains largely unknown. A polysaccharide-producing Agrobacterium sp. was investigated to gain insight into the regulatory factors governing polysaccharide biosynthesis. Agrobacterium sp. ATCC 31749 produces a pl,3-glucan polymer known as curdlan, which has applications in a wide-range of industries including food, cosmetics, materials, and medical. While Agrobacterium sp. is used industrially to produce curdlan for these commercial applications, very little is known about the genetics and regulatory processes of this microorganism. This study utilizes genomics and transcriptomics to analyze Agrobacterium sp. ATCC 31749 at the systems level, revealing a complex, multi-faceted regulatory mechanism for curdlan biosynthesis.