Beta-amino Acid Modified Heptapeptide Containing a Designed Recognition Element Disrupts Oligomerization and Fibrillization of the Amyloid Beta Peptide

摘要

Amyloid diseases such as Alzheimer's and type II diabetes are becoming of increasing concern in societies in which people are enjoying longer and more affluent lives (the latter leading to increasing obesity problems which predispose to conditions including type II diabetes). Amyloid diseases are believed to result from aggregation of misfolded proteins into β-sheet assemblies termed amyloid. In the case of Alzheimer's, intense research activity has pointed to the role of the amyloid β (Aβ) peptide (which occurs in plasma and cerebrospinal fluid