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Electrospinning of Bioresorbable Polymers for Tissue Engineering Scaffolds

机译:用于组织工程支架的生物可吸收聚合物的静电纺丝

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Since the inception of the field of tissue engineering, there has been a considerable effort to develop an "Ideal" tissue engineering scaffold. To date, investigators have developed materials such as collagen, poly(glycolic acid) (PGA), poly(lactic acid) (PLA), and polycaprolactone (PCL) for use in matrix construction with frequently unacceptable results. The construction of an "Ideal" tissue engineering scaffold requires that multiple criteria are met. The first criterion is that the material be biocompatible and function without interrupting other physiological processes. This functionality includes an ability to promote normal cell growth and differentiation while maintaining three-dimensional orientation/space for the cells. Additionally, the scaffold should not induce any adverse tissue reaction. Another criterion involves the production of the scaffold. Scaffold production must include efficient material and construction parameters. The construction must also involve a process by which the scaffold can be easily reproduced to a wide range of shapes and sizes. Once implemented in vitro or in vivo, the material should be
机译:自组织工程领域成立以来,有很大的努力来开发一个“理想”的组织工程支架。迄今为止,调查人员已经开发出胶原蛋白,聚(乙醇酸)(PGA),聚(乳酸)(PLA)和聚己内酯(PCL)的材料,其用于基质结构,其经常是不可接受的结果。构建“理想”组织工程脚手架要求满足多个标准。第一标准是材料是生物相容性的并且在不中断其他生理过程的情况下是生物相容性的。该功能包括促进正常细胞生长和分化的能力,同时保持细胞的三维取向/空间。另外,支架不应诱导任何不良组织反应。另一个标准涉及支架的生产。脚手架生产必须包括有效的材料和施工参数。结构还必须涉及一种过程,通过该过程可以容易地再现到各种形状和尺寸。一旦在体外实施或体内实施,材料应该是

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