Cell-based biosensors have the capacity to respond to a wide range of analytes in a physiologically relevant manner. By employing living cells as sensors, bioanalytes can be screened without requiring apriori knowledge of the analyte's chemistry. The ability to operate and screen for unknown analytes provides benefits in numerous applications, including pharmacology, cell biology, toxicology, and environmental monitoring. Recent studies have demonstrated that acoustic wave devices are capable of quantitatively probing the behaviors of cells attaching to sensor surface. Among various types of acoustic devices, Love mode sensor has many advantages in liquid environment. However, up to now, the use of Love mode devices as cell-based sensors is limited, including theoretical and experimental studies. In this study, we developed a theoretical model for cell-based Love mode sensors. The devices were designed, fabricated and utilized for cell adhesion monitoring.
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