CHEMOTHERAPY DRUG ENCAPSULATED POLY(LACTIC-CO-GLYCOLIC ACID) NANOPARTICLES

摘要

In order to exhibit pharmacological activity at the bone cancer site, high-dose chemotherapy drugs need to be used. This often causes toxicity and unfavorable systemic adverse effects leading to significant problems to the patient. Since nanoparticles are in subcellular size, they can effectively entered to the cell membrane that could result in higher cellular uptake. In this study, we report preparation and characterization of poly (lactic-co-glycolic acid) -PLGA nanoparticles, which encapsulated with chemotherapy drug cisplatin.