Photodynamic combination therapy vs. simple ND:YAG laser for the treatment of cancer of the urinary bladder

摘要

The authors report that 41 patients with cancer of the urinary bladder were treated with YAG, hematoporphyrin derivative (HPD) photodynamic combination therapy (combination group) and simple YAG laser (simple group). Forty-one cases were divided into 2 groups: 20 cases in the combination group (31 tumors) and 21 cases in the simple group (26 tumors). A follow-up survey was made for 12 - 36 months after treatment. In the combination group 2 cases in 12 months and another 2 cases in 24 months showed no recurrence. Sixteen cases were followed up for 29 to 36 months with 2 recurrent cases. The 36-month recurrence rate in the combination group was 12.5%. In the simple group recurrences took place in 2 out of 6 cases during the follow-up of 13 to 16 months after treatment. The 24-month recurrence rate was 33.3%. Recurrences were observed in 8 out of 15 cases followed up for 31 - 36 months. The 36-month recurrence rate in the simple group was 53.3%. There was significant difference in the 36-month recurrence rate. The results indicate that the combination group is highly superior to the simple group for a long-lasting therapeutic effect on bladder cancer. The follow up is reported in this paper.