Photodynamic effects of Can-Sha photosensitizer on transplanted tumors in mice

摘要

Can-sha photosensitizer (CPS) extracted from the silkworm excreta (a Chinese herb) was administered to tumor bearing mice by iv or the intragastrointestinal route in dosages of 50 mg/kg and 550 mg/kg, respectively. Six to ten hours later the tumorous site was irradiated with light. The results showed that the tumor inhibition rates were 69 - 98% by iv and 62 - 79% by intraduodenal (id) injection, but no photodynamic effect was found in the tumors of mice after administering CPD by p.o. $+3$/H-TdR or $+3$/-uR incorporation ability of the tumor cells pretreated with the drug and light was significantly inhibited.