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Autologous bone marrow transplantation by photodynamic therapy

机译:光动力疗法自体骨髓移植

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Simultaneous exposure of Merocyanine 540 dye containing cultured tumor cells to 514-nm laser light (93.6 J/cm$+2$/) results in virtually complete cell destruction. Under identical conditions, 40% of the normal progenitor (CFU-GM) cells survive the treatment. Laser-photoradiation treated, cultured breast cancer cells also were killed, and living tumor cells could not be detected by clonogenic assays or by anti-cytokeratin monoclonal antibody method. Thus, laser photoradiation therapy could be useful for purging of contaminating tumor cells from autologous bone marrow.
机译:将含有培养的肿瘤细胞的Merocyanine 540染料同时暴露于514-nm激光(93.6J / cm $ + 2 $ /),导致几乎完全的细胞破坏。在相同的条件下,40%的正常祖细胞(CFU-GM)细胞存活治疗。激光光学处理处理,培养的乳腺癌细胞也被杀死,并且不能通过克隆发生的测定或通过抗细胞角蛋白单克隆抗体方法检测活肿瘤细胞。因此,激光光敏疗法可用于从自体骨髓中吹扫污染肿瘤细胞。

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