Polymorphism of PrP Gens in the Population of Chamois in the Area of Biokovo - Republic of Croatia

摘要

Transmissible Spongiform Encephalopathies (TSEs) are a group of contagious neurodegenerative diseases that attack neural tissue by the formation of aggregates of prion particles in it. The final outcome of these diseases is lethal. Causative agent is prion, a cellular glycoprotein which have two forms, not contagious with the a - projection, denoted PrP~C and infectious with the (3 -folded plate and labeled PrP~(Sc). This disease is characteristic for many mammals and humans also. Research has shown that there are genetic predispositions to disease or resistance to it. In the case of goats, various codons that may be associated with disease resistance are reported in the literature, mostly for codon 146. In the study of polymorphisms in chamois, the same information as for goats was used. The genomic DNA was used in the study, which was isolated from the full blood of animals and was subjected to a polymerase chain reaction with specially designed primers. The populations of the chamois have shown that the investigated population is monomorphic when it comes to PrP gene.