Comparison of machine learning models for the prediction of cancer cells using MHC class I complexes

摘要

Currently, cancer is the leading cause of death worldwide, making millions of deaths annually in developing countries due to a shortage of detection and treatment. Early detection of cancer neoantigens is useful for specialists because they can help in the development of more successful treatments. Based on this problem, the objective of this work is to carry out a comparative process between machine learning models, to determine which of them allows an adequate prediction of the data, and thus determine the carcinogenic neoantigens. For this, information extracted from protein sequences was employed. The preliminary results show sensitivity and specificity of 1.0 and 0.98 respectively.