Fabrication Drug Loaded Polycaprolactone Microparticles by Electrospraying Method

摘要

The drugs such as Insulin and Paclitaxel were encapsulated in Polycaprolactone (PCL) by electrospraying method. Some fabricated factors which influenced the morphology of PCL microparticles were investigated. Electrospraying is an effective and approachable method to produce considerable solid drug-loaded microparticles for drag delivery system. Using the Scanning electron microscopy to observe the morphology and size of particles and Thermal Analysis evaluated the compatibility of drug and polymer matrix. The toxicity of products was determined by checking the existence of solvent inside the electrosprayed particles. The results showed that the drug-loaded microspheres were fabricated at 15-20% drug (w/w), 4.5% PCL in Dichloromethane. Besides, the hydrophobic drag (Paclitaxel) had a good compatibility with PCL matrix, therefore, the surface of particles was smoother. In case of Insulin, it and PCL created a suspension and consequently generated the undesirable morphology with holes and wrinkled surfaces. The drug-loaded microparticles didn't contain toxic solvent so that it can be applied in pharmacy.