Engineering of Hollow Mesoporous Silica Nanoparticles Enhancing Drug-Loading Capacity

摘要

Hollow mesoporous silica nanoparticle (HMSN) has been rec-ognized as an outstanding candidate for improving the drug loading capacity of silica nanoplatforms. This study reports the synthesis of hollow mesoporous silica nanoparticles (HMSN) as a potential bioactive to improve the drug loading capacity of the nanoparticles delivery systems. Herein, HMSN was success-fully synthesized by using tetraethyl orthosilicate (TEOS) and cetyltrimethyl ammonium bromide (CTAB). The prepared HMSN nanocarriers were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS). thermogravimetric analysis (TGA), and fourier trans-form infrared (FTIR). In aqueous solution, HMSN existed as nanoparticles with morphology, spherical shape and the diam-eter range of 180-200 nm. Especially, RhB was effectively en-capsulated into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) with high loading efficiency. These results demonstrated that this prepared HMSN nanocarrier may serve as a promising nanocarrier with high drug loading capacity for its potential applications in drug delivery.