Biological sensing technology based on intrinsic molecular charges

摘要

In this paper, we report a biosensing method to analyze and monitor simply and easily biological phenomena such asDNA recognition events, antigen-antibody reaction, and cell functions in vitro by use of a semiconductor device. As themost important point, we focus on a direct detection of ions or ionized biomolecules with charges, because mostbiological phenomena are related to ionic behaviors such as sodium or potassium ions through ion channel at cellmembrane resulted from cell-cell communications, and biomolecules such as DNA molecules have intrinsic molecularcharges. That is, the principle of semiconductor-based biosensing device contributes to directly detect biomolecularcharges. Thus, a platform based on the semiconductor-based biosensor is suitable for a label-free and noninvasivebiosensing detection system in the field of in vitro diagnosis (IVD).