MULTIPLE REACTIONS FOR THE ASYMMETRIC SYNTHESIS OF UNUSUAL AMINO ACIDS

摘要

Unusual amino acids, such as γ-amino butyric acid (GABA) derivatives and hydroxy amino acids, are known to have worthwhile physiological activities on the mammals or are used as chiral building blocks in the chemical synthesis of other compounds. So far, we have been screening microbial enzymes in order to develop novel biocatalysts useful for various kinds of bioproduction process. In the course of the screening, a variety of enzymes were found to catalyze unique reactions acting to amino acids and the related compounds. Therefore, we suitably combined these biocatalysts and chemical reactions to make multiple reaction systems, by which several unusual amino acids were obtained with high steric purity.