SYNTHETIC BIOLOGY OF MODULAR ENZYMES: FROM ENZYMES TO ENZYBIOTICS

摘要

Over the past few years antimicrobial resistance has evolved from a rare event to an everyday occurring problem in health care. The future looks even more grim due to the increase of antimicrobial resistance against antibiotics and the unprecedented discovery void of new antibiotic classes. Enzyme-based antimicrobials or enzybiotics represent a novel class of antibacterials. Specifically, endolysins encoded by bacterial viruses (bacteriophages) that degrade the peptidoglycan layer, have gained tremendous interest with many proof-of-concept studies up to clinical phase studies.