Polymeric Carriers - The Influence of Body Fluid Compounds on a Drug Local Release

摘要

The release of a model compound (cyanocobalamin) from the core-shell structure of drug carrier was considered. Mass transfer was described by the classical equation describing a diffusion mass flow. The presence of compounds found in body fluids on the diffusional mass stream was investigated. It has been shown that high molecular weight compounds unable to penetrate the carrier surface form on the carrier surface a layer that slightly slows the drug release. Slowing down also occurs in the case of counter-current transport of soluble organic components. However, the salts (particularly NaCl) present in body fluids, probably due to the emerging osmotic pressure, significantly accelerate the transport of the released drug. In order to prevent this phenomenon, salts at the concentrations equal to their concentrations in the fluid surrounding the carrier should be placed into the carrier.