A Cell-Sensory Bioscaffold of Biocompatible Titanate Nanofiber

摘要

To date, little has been reported in literature about turning a bioscaffold into an electrochemical sensor, because often the bioscaffolds are electrochemically inactive. An ideal cell-sensor criteria is to be simple, sensitive, reliable, directly adaptable to pathological clinic, and easily fabricated in a large scale at low-cost. For over a decade, the titanate nanowire has been proven as a bioscaffold of the new type for applications in the implants, cosmetic, and pharmaceutical fields. In the present work, the titanate nanofibers were first of all grown on top of an implantable titanium metal, and characterized by means of SEM, XRD, etc. In an aqueous phospate buffer saline (PBS), the as-made bioscaffold showed a characteristic electrochemical impedance spectrum as a baseline. After being incubated with the human breast cells, a new impedance spectrum was recoded, suggesting that upon binding onto the bioscaffold the cells have altered the surface charge-density across the nanofiber-bioscaffolds. This exciting and long-overdue change in the electrochemical signal has been realized for the first time on such a bioscaffold. This new method can be potentially used in various important applications in future cancer screening and monitoring in vitro and in vivo at ultra-low-cost and in real-time, which seems promising and exciting.