UV-LED-Based Fluorescence and Reflectance Sensor System for Dermatological Diagnostics

摘要

A fiber optical, UV-LED-based, spectroscopic fluorescence sensor system for diagnostic applications in dermatology has been developed and tested at excised human skin lesions. The system uses seven LEDs in the wavelength range 300...430 nm to excite autofluorescence of different fluorophores in human skin. Additionally, the skin's diffuse reflectance is measured by means of a tungsten halogen lamp to correct reabsorptions of the fluorescence emission in the skin itself. Moreover, the system includes a dermatoscope to take photographs of the lesions. The setup is primary meant for the distinction between healthy skin and nonmelanoma skin cancer (NMSC) in vivo but may also be useful for other disorders like malignant melanomas and psoriasis. Results of first clinical ex vivo measurements are discussed.