FABRICATION AND CHARACTERIZATION OF 3-D POROUS HYDROXYAPATITE (HA)-MODIFIED POLYURETHANE (PU) SCAFFOLD FOR TISSUE ENGINEERING

摘要

In this work,the 3-D porous hydroxyapatite (HA)-modified polyurethane (PU) scaffold successfully fabricated by using simple ultrasonic assisted method.The hydrophilcity,water absorption and mechanical properties of HA-modified PU scaffold were significant higher than those of PU scaffolds.Compared with PU scaffold,the addition of HA nanoparticles could effectively improve the attachment and growth of human umbilical vein endothelial cells (HUVECs) cultured on the HA-modified PU scaffold.These results suggest that HA-modified PU scaffold possesses a great potential to be used as tissue engineering scaffold and the ultrasonic assisted technique could be a simple,effective and universal method to decorate the tissue engineering scaffold.