Modeling and Simulation of Magnetic Nanoparticles Transport in a Channel for Magnetic Drug Targeting

摘要

In this work, a mathematical model is presented to calculate the capture efficiency of magnetic nanoparticles in a channel for magnetic drug targeting (MDT). The magnetic nanoparticles are injected into a channel and captured help of an applied magnetic field. The dominant magnetization and drag forces acting on magnetic particles are incorporated to study the transport of magnetic particles under magnetic field. The value of capture efficiency, calculated through mathematical model, is found to be increases from 22 and 67% as we increase the magnetic field from 1 to 10 kOe. Further, trajectories and capturing of magnetic nanoparticles under magnetic field are also predicted via simulations performed through finite element based COMSOL software. Simulations results also show the enhancement in capture efficiency with magnetic field.