Protein glycosylation contributes to protein folding, stability, localization and interaction. The glycoprotein quality control in the endoplasmic reticulum (ER) is essential for their folding, sorting and degradation. A central quality control machinery of the nascent glycoprotein is the calnexin/calreticulin cycle (Figure 1). This cycle monitors glycan structure and assists and checks the protein folding. However, the mechanisms that release the misfolded glycoproteins from the cycle remain unclear.
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