DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin present on the surface of immature dendritic cells and plays a key role in the immune system and viral infections. The main carbohydrate ligand recognized by DC-SIGN is the high-mannose glycan, (Man)9(GlcNAc)2, with the mannosyl nonasaccharide (Man9) being the main epitope to interact with this receptor. Our research group is interested in the interaction, both blocking and internalization, of the multivalent sugar-decorated glycoconjugates with this lectin due to the enormous relevance in many biological applications. In this work, we proposed the use of glycodendritic systems as tools in biomedicine, in particular.
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