SYNTHESIS AND CHARACTERIZATION OF NEW COPPER(I) COMPLEXES COMPRISING CARBOHYDRATES FOR CANCER THERAPY

摘要

In the field of metallodrugs cisplatin in one of the leading chemotherapeutics with well-established efficacy against a variety of cancers. Despite the clinical success, its use is limited due to severe side effects. Copper complexes have attracted much interest as alternative chemotherapeutic drugs. During the recent years our group has been committed to the discovery of new copper(l)-phosphane derived complexes, most of which revealed higher cytotoxicity than cisplatin against ovarian and breast cancer cell lines [1].