SYNTHESIS OF CHONDROITIN SULFATE DENDRIMERS AND BINDING TO GROWTH FACTOR MIDKINE

摘要

Chondroitin sulfate (CS) is a very heterogeneous polysaccharide that is involved in numerous biological processes, such as cancer, neuroregeneration and inflammation. The biological functions of this biopolymer are due to the interactions between specific oligosaccharide sequences and a wide range of proteins. For this reason, there is a great demand for the synthesis of homogeneous CS oligosaccharides. However, the preparation of long sequences is still a complicated task. In this context, the development of glycomimetics that retain, or even increase, the biological activity of natural sequences and, at the same time, can be easily prepared in comparison with the natural oligosaccharides is highly desirable.