APPLICATIONS OF ORGANOCATALYSTS IN CARBOHYDRATE CHEMISTRY

摘要

This talk will describe our group's efforts to develop organocatalyzed reactions for use in carbohydrate chemistry [1]. We have developed a simple cheap organocatalyst that is effective at 0.1 mol% for the stereoselective synthesis of 2-deoxygalactosides. This methodology has been applied on a gram scale , and enables the synthesis of 1,1'-linked trehalose type disaccharides, as well as the glycosylation of steroids and amino acids. We have investigated the mechanism of this reaction and these results will be described [2].