Polyester Glycodendrimers and Dendronized Polymers as Potential Antiadhesion Drugs Against Urinary Tract Infections

摘要

Particular strains of E. coli are the major cause of urinary tract infections (UTI) and infection is initiated by attachment of the protein FimH at the terminus of Type 1 pili to the terminal α-D-mannopyranose (α-D-Manp) unit of trimannosides attached to the protein uroplakinla on the surface of the urinary tract. Particular ot-D-Manp or α-D-Manp-(1->3)-β-D-Manp- derivatives have been identified that bind well to FimH. Such compounds are potential antiadhesion drugs against UTIs and some have been shown to be effective for the treatment of UTIs.