NOVEL TRIAZOLYL GLYCOHYBRIDS WITH ALLO-, GALACTO- AND GULO- CONFIGURATION

摘要

Since discovery of synthetic nucleoside tiazofurin and its analogs ribavirin, eicar and bredin that show antiviral and antitumour activities sugar-heterocycle adducts have drawn substantial synthetic interest in medical chemistry. Among other azoles, 1,2,3-triazole moiety has gained an undivided interest in recent years. Our studies were focused on glycohybrids with triazole heterocycle at C(3) in hexapyranoses, what is not so broadly described in the literature. There are only few examples dealing with C-3-triazolylglycoconjugates.