Osteoconductivity of New Sodium Calcium Phosphate Pastes

摘要

We are developing a new bone paste (CaNaP paste), consists of calcium sodium phosphate(CaNaPO_4), alpha-TCP, beta-TCP and citrate. It has improved handling and mechanical property with decreased setting time. For in vivo analysis using a rabbit model, four kinds of materials (Material 1: CaNaPO_4 + alpha, beta-TCP + citrate, Material 2: commercially available CaP paste, Material 3: CaNaPO_4 + alpha-TCP + citrate, and Material 4: commercially available porous beta-TCP) were prepared, and they were implanted into the rabbit femoral condyles (n=8). After 4 weeks and 12 weeks, histo-morphometrical analyses were performed, and bone-material contact index, bone area in the material, bone area ratio around the material, degree of bone penetration into the material, and material absorptivity were calculated. Results showed that Material 1 (newly developed CaNaP pasted containing beta-TCP) is more osteoconductive than Material 2 and Material 3 (CaNaP paste without beta-TCP), and can be expected as an attractive alternative for the bone substitute material.