Virus filtration is a well-established method for minimizing the inherent risk of viral contamination in the production of both therapeutic proteins and potable water. Although virus filters remove viruses primarily on the basis of size, the extent of virus retention can vary significantly over the course of the filtration or in response to changes in operating conditions. Several studies have reported a significant decline in vims retention during constant pressure virus filtration with certain filters. More recently, limited experiments showed that a temporary release in the transmembrane pressure caused a significant increase in transmission of both porcine parvovirus (PPV) and encephalomyocarditis virus (EMCV). However, there is currently no detailed understanding of the factors controlling this phenomenon or the underlying physical basis for the observed increase in transmission.
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