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Extending the Algebraic Formalism for Genome Rearrangements to Include Linear Chromosomes

机译:延长基因组重排的代数形式主义,以包括线性染色体

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Algebraic rearrangement theory, as introduced by Meidanis and Dias, focuses on representing the order in which genes appear in chromosomes, and applies to circular chromosomes only. By shifting our attention to genome adjacencies, we are able to extend this theory to linear chromosomes in a very natural way, and extend the distance formula to the general multichromosomal case, with both linear and circular chromosomes. The resulting distance, which we call algebraic distance here, is very similiar to, but not quite the same as, DCJ distance. We present linear time algorithms to compute it and to sort genomes. We also show how to compute the algebraic distance from the adjacency graph. Some results on more general k-break distances are given, with algebraic distance being 2-break distance under our interpretation.
机译:由meidanis和Dia引入的代数重排理论侧重于代表基因出现在染色体中的顺序,仅适用于圆形染色体。通过将我们的注意力转移到基因组邻接,我们能够以非常自然的方式将该理论扩展到直链染色体,并将距离配方延伸到一般多体组件,具有线性和圆形染色体。我们在此调用代数距离的所得到的距离非常类似,但与DCJ距离相同。我们呈现线性时间算法来计算它并进行分类基因组。我们还展示了如何计算距离邻接图的代数距离。在我们的解释下给出了更多普通k断裂距离的结果,以代数距离为2距离。

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