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Extending the Algebraic Formalism for Genome Rearrangements to Include Linear Chromosomes

机译:扩展基因组重排的代数形式主义,以包括线性染色体

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Algebraic rearrangement theory, as introduced by Meidanis and Dias, focuses on representing the order in which genes appear in chromosomes, and applies to circular chromosomes only. By shifting our attention to genome adjacencies, we are able to extend this theory to linear chromosomes in a very natural way, and extend the distance formula to the general multichromosomal case, with both linear and circular chromosomes. The resulting distance, which we call algebraic distance here, is very similiar to, but not quite the same as, DCJ distance. We present linear time algorithms to compute it and to sort genomes. We also show how to compute the algebraic distance from the adjacency graph. Some results on more general k-break distances are given, with algebraic distance being 2-break distance under our interpretation.
机译:由Meidanis和Dias提出的代数重排理论着重于代表基因在染色体中出现的顺序,并且仅适用于圆形染色体。通过将注意力转移到基因组邻接上,我们能够以非常自然的方式将此理论扩展到线性染色体,并将距离公式扩展到具有线性和环状染色体的一般多染色体情况。所得的距离(在此我们称为代数距离)与DCJ距离非常相似,但并不完全相同。我们提出了线性时间算法来对其进行计算和对基因组进行排序。我们还展示了如何从邻接图计算代数距离。给出了一些关于更一般的k断裂距离的结果,根据我们的解释,代数距离是2断裂距离。

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