Development of Carbon Dots Modified Fluorescent Molecular Imprinted Polymer@Ag/AgCl Nanoparticle For Hepatocellular Carcinoma Marker

摘要

In this work, a sensitive and selective fluorescent molecularly imprinted polymer (MIP) was developed for detection of hepatocellular carcinoma (HCC) biomarker i.e. alpha feto protein (AFP) using Ag/AgCl as platform. Here, the carbon dots and Ag/AgCl nanoparticles were functionalized with vinyl groups and used as functional monomer for synthesis of AFP-imprinted polymer. The imprinted polymer shows a linear range of 3.96 ng mL~(-1)to 80.0 ng mL~(-1) with detection limit of 0.42 ng mL~(-1).The adsorption property of the MIP@Ag/AgCl was studied and shows the high affinity binding towards their target analyte without any cross-reactivity and false-positive or false-negative results.