Investigation of xFe_2O_4 (x= Mn, Co) Doped Hydroxylapatite Ferromagnetic Biomaterials for the Treatment of Damaged Bone and Magnetically Targeted Drug Delivery Systems

摘要

Magnetically attracted MnFe_2O_4 and CoFe_2O_4 doped hydroxylapatite samples have been prepared by using co-precipitation method in the laboratory. Bioactive nature of samples has been confirmed from XRD spectra. Ferromagnetic behavior of samples has been studied by using vibration sample magnetometer. Human osteoblast cell line MG63 has been used to explore the cell viability of samples. Drug carrier ability of samples has been checked with gentamycin as an antibiotic and results show that samples can be used as excellent drug carriers. Drug loaded samples can be easily targeted to specific area due to their attractive nature towards external magnetic field. Our results indicate that prepared samples possess good bioactive as well as ferromagnetic behavior with drug carrier ability and hence, our samples can be potential candidates for the clinical applications.