Nucleation Control and Growth of Metastable α-L-Glutamic Acid Single Crystals in the Presence of L-Tyrosine

摘要

The influence of selective additive L-tyrosine on the nucleation control of L-glutamic acid polymorphs from aqueous solution was studied. The effect of different additive concentrations on the solubility, pH and induction period of nucleation of the polymorphs was also investigated. Nucleation control of the polymorphs was successfully carried out and single crystals of metastable α-polymorph were grown. Structural confirmation of the grown polymorph was carried out by X-ray powder diffraction study.