Despite a growing recognition that meniscal degeneration often precedes cartilage degeneration in the development of knee osteoarthritis (OA), little is known about the role of meniscal degeneration in the onset and progression of knee OA. Even a mild degenerative lesion increases meniscal extrusion, implying changes in biomechanical function. Understanding the mechanisms of meniscal degeneration may enable the diagnosis and disease-modifying treatment of early knee OA, potentially preventing or slowing the progression of the disease. The roles of pro-inflammatory cytokines such as interleukin-1 (IL-1) in promoting cartilage matrix degradation and mediating inflammation in the progression of OA have been widely demonstrated [1,2]. Recent results from our group indicated that 20ng/ml hrIL-1α produced similar cell-mediated degradation and loss of mechanical properties in immature cartilage and meniscus, but progresses more rapidly in meniscus explants [3]. This study further explored the effects of IL-1α dosage and medial-lateral differences on the functional degradation of meniscal explants.
展开▼
机译：尽管越来越认识到膝关节骨关节炎（OA）的发育中的软骨变性常见于软骨变性之前，但对膝关节OA发作和进展的半月板变性的作用很少。即使是轻度退行性病变也会增加半月板挤出，暗示生物力学功能的变化。了解半月板变性的机制可以使诊断和疾病改性治疗早期膝盖OA，可能预防或减缓疾病的进展。促炎细胞因子如白细胞介素-1（IL-1）的作用在OA进展中促进软骨基质降解和介导炎症的促进[1,2]。我们组最近的结果表明，20ng / ml HRIL-1α在未成熟的软骨和半月板中产生了类似的细胞介导的降解和机械性能损失，但在弯月面外植物中更快地进行了进展[3]。该研究进一步探讨了IL-1α剂量和内侧横向差异对半月板外植体的功能降解的影响。
展开▼
