EFFECTS OF ARTERIAL GEOMETRY ON INFLOW RATE INTO CEREBRAL ANEURYSMS ON CURVED ARTERIES

摘要

Pathobiological studies have demonstrated that atherosclerotic lesions have been found on the wall of saccular cerebral aneurysms [1]. We propose a hypothesis that some of these aneurysms are prevented from rupturing due to the atherosclerotic lesions. It has been presented that mass transport of biochemical species such as LDL and ATP, has some important roles in the development of atherosclerosis. A variety of Computational Fluid Dynamics (CFD) studies of the mass transport has been performed for arteries [2, 3], few studies have however, done for aneurysms. In this paper, we numerically analyze inflow rate into saccular cerebral aneurysms on curved arteries. In particular, effects of arterial geometry on the inflow rate are discussed. For most the biochemical species that are assumed to relate to atherosclerosis, advective transport is dominant because of their very small diffusion coefficients. The understandings of flow rate into aneurysms thus, provide valuable information for any mass transport problems of biochemical species with high Peclet numbers.