(cest2017_00954) Photocatalytic degradation of psychoactive drugs Alprazolam, Bromazepam and Diazepam by PhotoFenton

摘要

Photo-Fenton has emerged as a prominent strategy for thetreatment of drugs and their metabolites. Benzodiazepinesand their metabolites represent a significant group ofemerging environmental pollutants due to their stability,continuous discharge in the environment and their lowremoval rates by conventional biological wastewatertreatment plants. The objectives of the study were a) tooptimize the efficiency of the photo catalytic oxidation ofthree psychiatric pharmaceuticals Alprazolam,Bromazepam and Diazepam using response surfacemethodology, b) to evaluate the degradation kinetics of thePhoto Fenton reaction and c) to examine the effect ofvarious parameters that affect the efficiency and the rate ofthe oxidative process. To evaluate the degradation rates ofthe three drugs, a central composite design was selected inorder to observe the effects of Fe2+ and H_2O_2. DifferentH_2O_2: Fe2+ molar ratios were examined for their kineticbehavior, which was described effectively by pseudo firstorder kinetic models. The impact of the factors affectingthe rates of oxidation of the three drugs such as differentiron sources and initial drug concentrations was alsoinvestigated.