HORMESIS INDUCED BY MIXTUES OF IONIC LIQUIDS WITH SIGMOID DOSE-RESPONSE CURVE

摘要

Hormesis is a dose-response phenomenon that is characterized by low-concentration stimulation and high-concentration inhibition. The concept of hormesis has generated considerable interest in recent years. This is principally because the hormetic dose-response model challenges the linear at low-dose model employed by regulatory agencies such as the EPA and FDA in cancer risk assessment activities and the sigmoid curves employed by most of researchers when assessing the toxicities of pollutants. So, it is of vital importance to explore more hormesis within the chemicals. Room-temperature ionic liquids (JLs) are a fascinating group of new chemicals. The great interest for such compounds is the potential substitution for traditional organic solvents and their fame of "green" solvents. However, ILs is not always green. More and more studies showed that the potential (eco)-toxicological hazard and risks of ILs cannot be neglected. In our previous study, we found the IL: 1-ethyl-3-methylimidazolium bromide ([emim]Br) and tetrafluoroborate ([emim]BF4) can cause remarkable hormesis phenomenon towards the luminescent inhibition toxicity of Vibrio qinghaiensis sp.-Q67 (Q67). To explore more hormesis phenomenon within ILs, we investigated the single toxicity and combined toxicity of another group of IL with different alkyl-chain length on the cation, [emim]Cl, [bmim]Cl, [hmim]Cl, and [omim]Cl, to Q67 by employing the microplate toxicity analysis (MTA) procedure. The four ILs were selected as the testing materials based on our previous results, which showed the mixture rays containing the ILs exhibits antagonism and their toxicities depend on the concentration ratio of the IL, [hmim]Cl. Therefore, a series of ternary and binary IL mixture rays with or without the decisive EL were designed at different component-concentration ratio by using the uniform-design-concentration-ratio (UDCR) ray method.