(00306)Air Pollution Exposures and Respiratory Health in 5-Year-Old Children

摘要

Background: Growing evidence indicates that respiratory health in children is related to air pollution. Most of previous studies rely on residential air pollution estimates to represent individual exposure; however, there is evidence that residential estimates tend to misclassify exposure. Aim: This study aims to assess the relations between air pollution exposures and respiratory health (asthma, wheezing and lung function)by applying a sophisticated exposure assessment technique. Methods: The study relies on a Dutch cohort and includes 733 children. The prevalence of asthma and wheezing and the spirometry measurements were determined at the age of 5. The annual average concentration maps of Particulate Matters and Nitrogen Oxides that we used in the study were derived from the European Study of Cohorts for Air Pollution Effects. To assess individualized air pollution exposures an updated exposure assessment technique was applied. Results: This study did not show significant associations between air pollution exposures and the studied health outcomes in the 5-year olds. For example, after adjusting for possible confounders, the ORs were 1.2 (95% CI: 0.86, 1.61)and 1.2 (95% CI: 0.87, 1.64)for wheezing prevalence for NO_x and PM2.5 respectively.