The aim of our study was to evaluate the outcome of node-negative gastric cancer. We retrospectively analysed data on 278 patients (157 males and 121 females, with a mean age of 65+-11 years) with node-negative gastric cancer who underwent curative gastric resection at San Raffaele Hospital of Milan, between 1987 and 2004. The surgical procedure consisted of 39 (14%) total and 239 (86%) subtotal gastrecto-mies. The extent of lymph node dissection was limited Dl (n=120, 43%) or extended D2 (N=152, 55%) and D3 (n=6, 2%). The mean number of examined lymph nodes was 16. In the univariate analysis, extension of lymphadenectomy did not influence survival. The overall survival rate was 94%, 80%, and 61% at 1, 5, and 10 years. The T stage affected survival (log rank test: p less than 0.001). CONCLUSIONS: in our experience the extension of lymphadenectomy did not influence survival of patients submitted to curative resections for node-negative gastric cancer.
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