Extracts from the Root of Platycodon grandiflorum Modulate Induction of Inflammatory Changes in Coculture of Adipocytes and Macrophages

摘要

The root of Platycodon grandiflorum has been consumed as food stuff in East Asia as traditional oriental medicine for diseases such as bronchitis, asthma, pulmonary tuberculosis, hyperlipidemia, diabetes and inflammatory disease. Recently, extracts from the roots of P. grandiflorum (PGE) have been found to posses various biological properties, including anti-inflammatory, antiobesity, antiallergic and cholesterol-lowering activities. However, the mechanisms of the beneficial effect of P. grandiflorumremain unclear.