Effects of Lupeol on Melanoma In Vitro and In Vivo: Fundamental and Clinical Trials

摘要

The studies on tumor cell differentiation provide useful information for the preclinical evaluations of potent anticancer agents. Malignant melanoma is known to be one of difficult tumor to cure. Lupeol, a lupane triterpene, is widely distributed in plant kingdom, and recently found to suppress the tumor progressions in vitro and in vivo. We previously reported that lupeol induced mouse melanoma cell differentiation, and inhibited the proliferation and motility of melanoma cells in vitro. In the present study, we examined the differentiation-inducing activities of lupeol against melanoma cells in vitro and its clinical effects on the dogs with spontaneous melanoma.