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A heterogeneous optimization algorithm for reacted singlet oxygen forinterstitial PDT

机译:反应单次氧气流入PDT的异构优化算法

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Singlet oxygen (~1O_2) is the major cytotoxic agent for type II photodynamic therapy (PDT). The production of ~1O_2 involves the complex reactions among light, oxygen molecule, and photosensitizer. From universal macroscopic kinetic equations which describe the photochemical processes of PDT, the reacted ~1O_2 concentration, [~1O_2], with cell target can be expressed in a form related to time integration of the product of ~1O_2 quantum yield and the PDT dose rate. The object of this study is to develop optimization procedures that account for the optical heterogeneity of the patient prostate, the tissue photosensitizer concentrations, and tissue oxygenation, thereby enable delivery of uniform reacted singlet oxygen to the gland. We use the heterogeneous optical properties measured for a patient prostate to calculate a light fluence kernel. Several methods are used to optimize the positions and intensities of CDFs. The Cimmino feasibility algorithm, which is fast, linear, and always converges reliably, is applied as a search tool to optimize the weights of the light sources at each step of the iterative selection. Maximum and minimum dose limits chosen for sample points in the prostate constrain the solution for the intensities of the linear light sources. The study shows that optimization of individual light source positions and intensities is feasible for the heterogeneous prostate during PDT. To study how different photosensitizer distributions as well as tissue oxygenation in the prostate affect optimization, comparisons of light fluence rate were made with measured distribution of photosensitizer in prostate under different tissue oxygenation conditions.
机译:单线酸氧(〜1O_2)是II型光动力治疗(PDT)的主要细胞毒性剂。 〜1O_2的产生涉及光,氧分子和光敏剂之间的复杂反应。来自描述PDT的光化学过程的通用宏观动力学方程,具有细胞靶的反应〜1O_2浓度[〜1O_2],可以以与〜1O_2量子产量的产物和PDT剂量率的时间结合相关的形式表达。本研究的目的是开发出于患者前列腺的光异质性,组织光敏剂浓度和组织氧合的优化程序,从而使均匀反应的单次氧气赋予腺体。我们使用针对患者前列腺测量的异质光学性质来计算光线流量的核。几种方法用于优化CDF的位置和强度。快速,线性和始终可靠地收敛的CIMMINO可行性算法作为搜索工具应用,以优化迭代选择的每个步骤的光源的权重。对于前列腺中的样品点选择的最大和最小剂量限制限制了线性光源的强度的解决方案。该研究表明,在PDT期间,各个光源位置和强度的优化是异构前列腺的可行性。为了研究如何不同的光敏剂分布以及前列腺作用影响优化的组织氧合,在不同组织氧合条件下,使用前列腺激素分布的光敏剂分布进行了光增量的比较。

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