Our findings are completely novel and demonstrate the insights that can be derived from mass spectrometric analysis directly from tissue. Recently, ceramide-1-phosphate was observed to be upregulated in human tumor cell lines that received gamma-irradiation or chemotherapy[5]. Ceramide-1-phosphate is a signaling lipid, involved in the activation of inflammation related genes, tumorigenesis, cell migration, apoptosis, proliferation, chemotaxis, survival, and differentiation. Quantitative studies of lipids, metabolites and phosphoproteins on a global scale in this mouse model of liver carcinogenesis will be required to fully elucidate the role of ceramide-1-phosphate in heavy ion-induced pathogenesis.
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